Kristin Eckert
Professor, Department of Pathology and Laboratory Medicine and Department of Biochemistry and Molecular Biology
Interests
- Genome evolution
- Molecular mechanisms of carcinogenesis
Education
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Ph.D. in Oncology,
University of Wisconsin-Madison
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B.S. in Microbiology,
Penn State University
Biography
Prof. Eckert is focused on mechanisms of human cell mutagenesis and repetitive DNA replication in relation to genome evolution.
Publications
M Weissensteiner, MA Cremona, WM Guiblet, N Stoler, RS Harris, M Cechova, KA Eckert, F Chiaromonte, YF Huang, KD Makova.
Accurate sequencing of DNA motifs able to form alternative (non-B) structures.
GENOME RES,
2023.
ME Stein, A Nusawardhana, M Weissensteiner, M Leed, S Zhang, E Kejnovsky, I Kejnovská, KD Makova, KA Eckert.
Variation in G-quadruplex Sequence and Topology Differentially Impacts Human DNA Polymerase Fidelity.
DNA REPAIR,
2022.
WM Guiblet, M DeGiorgio, X Cheng, F Chiaromonte, KA Eckert, YF Huang, KD Makova.
Selection and thermostability suggest G-quadruplexes are novel functional elements of the human genome.
GENOME RES,
2021.
WM Guiblet, MA Cremona, RS Harris, D Chen, KA Eckert, F Chiaromonte, Y Huang, KD Makova.
Non-B DNA: A major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome.
NUCLEIC ACIDS RES,
2021.
WM Guiblet, MA Cremona, M Cechova, RS Harris, I Kejnovská, E Kejnovsky, KA Eckert, F Chiaromonte, KD Makova.
Long-read sequencing technology indicates genome-wide effects of non-B DNA on polymerization speed and error rate.
GENOME RES,
2018.
Regional variation Non-B DNA & Microsatellite Paper Link Press Release
A Fungtammasan, M Tomaszkiewicz, R Campos-Sánchez, KA Eckert, M DeGiorgio, KD Makova.
Reverse Transcription Errors and RNA–DNA Differences at Short Tandem Repeats.
MOL BIOL EVOL,
2016.
A Fungtammasan, G Ananda, SE Hile, MS-W Su, C Sun, RS Harris, P Medvedev, KA Eckert, KD Makova.
Accurate typing of short tandem repeats from genome-wide sequencing data and its applications.
GENOME RES,
2015.
G Ananda, SE Hile, A Breski, Y Wang, YD Kelkar, KD Makova, KA Eckert.
Microsatellite Interruptions Stabilize Primate Genomes and Exist as Population-Specific Single Nucleotide Polymorphisms within Individual Human Genomes.
PLOS GENET,
2014.
BA Baptiste, G Ananda, N Strubczewski, A Lutzkanin, SJ Khoo, A Srikanth, N Kim, KD Makova, MM Krasilnikova, KA Eckert.
Mature Microsatellites: Mechanisms Underlying Dinucleotide Microsatellite Mutational Biases in Human Cells.
G3-GENES GENOM GENET,
2013.
G Ananda, E Walsh, KD Jacob, MM Krasilnikova, KA Eckert, F Chiaromonte, KD Makova.
Distinct Mutational Behaviors Differentiate Short Tandem Repeats from Microsatellites in the Human Genome.
GENOME BIOL EVOL,
2013.
A Fungtammasan, E Walsh, F Chiaromonte, KA Eckert, KD Makova.
A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome?.
GENOME RES,
2012.
YD Kelkar, KA Eckert, F Chiaromonte, KD Makova.
A matter of life or death: How microsatellites emerge in and vanish from the human genome.
GENOME RES,
2011.
YD Kelkar, N Strubczewski, SE Hile, F Chiaromonte, KA Eckert, KD Makova.
What Is a Microsatellite: A Computational and Experimental Definition Based upon Repeat Mutational Behavior at A/T and GT/AC Repeats.
GENOME BIOL EVOL,
2010.