| The Makova Lab at Penn State

Jacob Sieg

Postdoctoral Scholar

Interests

Nucleic acids chemistry and biology
Molecular evolution
Non-canonical DNA secondary structures

Education

Ph.D. in Chemistry,

Penn State University
B.S. in Biochemistry,

Ohio Universisty Honors Tutorial College

Biography

Jacob’s current research in Makova Lab uses a combination of experimental and computational approaches to characterize the role of non-canonical DNA secondary structures in primate genomes. Before joining Makova Lab, Jacob studied RNA biochemistry. His Ph.D. thesis work with Dr. Philip Bevilacqua updated thermodynamic models that describe RNA secondary structures to better reflect the cellular environment. His undergraduate thesis work focused on drug targeting RNA thermometers in bacteria.