Obesity is becoming the major epidemic of the 21st century, and we are studying this disease in an integrated way - from the perspective of genomics, microbiomics, and epigenomics. We are following a large group of newborn children until they are at least 3 years of age, and will be finding genes linked to the development of obesity in some of them. This collaboration includes clinicians, statisticians, and social scientists to obtain a multifaceted picture of this important phenotype. Collaborators: Ian Paul, Francesca Chiaromonte.
Childhood obesity
Collaborators
Press Releases
New approach can help identify young children most at risk for obesity
UNIVERSITY PARK, PA. — Newly developed risk scores synthesize genetic information into an easy-to-interpret metric that could help …
Connecting the dots
Millions of tiny dots litter the canvas, each independently just a splotch of unmixed pigment but together a masterpiece of illusion …
Young children’s oral bacteria may predict obesity
The composition of oral microbiota – the collection of microorganisms, including beneficial bacteria, residing in the mouth …
Publications
D Lariviere, SJC Craig, IM Paul, E Hohman, JS Savage, RO Wright, F Chiaromonte, KD Makova, ML Reimherr.
Methylation profiles at birth linked to early childhood obesity.
J DEV ORIG HEALTH DIS,
2024.
SJC Craig, AM Kenney, J Lin, IM Paul, LL Birch, JS Savage, ME Marini, F Chiaromonte, ML Reimherr, KD Makova.
Constructing a polygenic risk score for childhood obesity using functional data analysis.
ECONOM STAT,
2023.
JS Savage, AK Hochgraf, E Loken, ME Marini, SJ Craig, KD Makova, LL Birch, IM Paul.
INSIGHT responsive parenting educational intervention for firstborns is associated with growth of secondborn siblings.
OBESITY,
2022.
D Nandy, SJ Craig, J Cai, Y Tian, IM Paul, JS Savage, ME Marini, EE Hohman, ML Reimherr, AD Patterson, KD Makova, F Chiaromonte.
Metabolomic profiling of stool of two-year old children from the INSIGHT study reveals links between butyrate and child weight outcomes.
PED OBESITY,
2022.
MC Carney, X Zhan, A Rangnekar, MZ Chroneos, SJ Craig, KD Makova, IM Paul, SD Hicks.
Associations between stool micro-transcriptome, gut microbiota, and infant growth.
J DEV ORIG HLTH DIS,
2021.
SJC Craig, AM Kenney, J Lin, IM Paul, LL Birch, JS Savage, ME Marini, F Chiaromonte, M Reimherr, KD Makova.
Polygenic risk score based on weight gain trajectories is a strong predictor of childhood obesity.
BIORXIV,
2019.
SJC Craig, D Blankenberg, ACL Parodi, IM Paul, LL Birch, JS Savage, ME Marini, JL Stokes, A Nekrutenko, M Reimherr, F Chiaromonte, KD Makova.
Child Weight Gain Trajectories Linked To Oral Microbiota Composition.
SCI REP-UK,
2018.
IM Paul, JS Williams, S Anzman-Frasca, JS Beiler, KD Makova, ME Marini, LB Hess, SE Rzucidlo, N Verdiglione, JA Mindell, LL Birch.
The Intervention Nurses Start Infants Growing on Healthy Trajectories (INSIGHT) study.
BMC PEDIATR,
2014.