Fig 1: Enrichment plot: KRAS.300_UP.V1_UP
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | de_results_collapsed |
| Phenotype | NoPhenotypeAvailable |
| Upregulated in class | na_neg |
| GeneSet | KRAS.300_UP.V1_UP |
| Enrichment Score (ES) | -0.4413816 |
| Normalized Enrichment Score (NES) | -2.0774407 |
| Nominal p-value | 0.0035273368 |
| FDR q-value | 0.083667 |
| FWER p-Value | 0.17 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | GLDC | glycine decarboxylase [Source:HGNC Symbol;Acc:HGNC:4313] | 244 | 4.817 | -0.0762 | No |
| 2 | SPRY2 | sprouty RTK signaling antagonist 2 [Source:HGNC Symbol;Acc:HGNC:11270] | 265 | 4.684 | -0.0388 | No |
| 3 | DDX6 | DEAD-box helicase 6 [Source:HGNC Symbol;Acc:HGNC:2747] | 676 | 3.522 | -0.2134 | No |
| 4 | MAP4K1 | mitogen-activated protein kinase kinase kinase kinase 1 [Source:HGNC Symbol;Acc:HGNC:6863] | 810 | 3.299 | -0.2481 | No |
| 5 | RETN | resistin [Source:HGNC Symbol;Acc:HGNC:20389] | 1014 | -3.559 | -0.3160 | No |
| 6 | TAPT1 | transmembrane anterior posterior transformation 1 [Source:HGNC Symbol;Acc:HGNC:26887] | 1055 | -3.618 | -0.2998 | No |
| 7 | GLRX | glutaredoxin [Source:HGNC Symbol;Acc:HGNC:4330] | 1332 | -4.145 | -0.3992 | Yes |
| 8 | ST3GAL6 | "ST3 beta-galactoside alpha-2,3-sialyltransferase 6 [Source:HGNC Symbol;Acc:HGNC:18080]" | 1345 | -4.180 | -0.3629 | Yes |
| 9 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 1459 | -4.454 | -0.3756 | Yes |
| 10 | DCBLD2 | "discoidin, CUB and LCCL domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24627]" | 1545 | -4.718 | -0.3712 | Yes |
| 11 | EVI2A | ecotropic viral integration site 2A [Source:HGNC Symbol;Acc:HGNC:3499] | 1590 | -4.847 | -0.3445 | Yes |
| 12 | LILRA6 | leukocyte immunoglobulin like receptor A6 [Source:HGNC Symbol;Acc:HGNC:15495] | 1617 | -4.940 | -0.3076 | Yes |
| 13 | G0S2 | G0/G1 switch 2 [Source:HGNC Symbol;Acc:HGNC:30229] | 1634 | -4.981 | -0.2651 | Yes |
| 14 | IL1RL1 | interleukin 1 receptor like 1 [Source:HGNC Symbol;Acc:HGNC:5998] | 1660 | -5.050 | -0.2266 | Yes |
| 15 | WNT7A | Wnt family member 7A [Source:HGNC Symbol;Acc:HGNC:12786] | 1756 | -5.506 | -0.2194 | Yes |
| 16 | RTN1 | reticulon 1 [Source:HGNC Symbol;Acc:HGNC:10467] | 1765 | -5.548 | -0.1671 | Yes |
| 17 | ADAM19 | ADAM metallopeptidase domain 19 [Source:HGNC Symbol;Acc:HGNC:197] | 1808 | -5.841 | -0.1292 | Yes |
| 18 | ARHGAP24 | Rho GTPase activating protein 24 [Source:HGNC Symbol;Acc:HGNC:25361] | 1841 | -6.097 | -0.0836 | Yes |
| 19 | ANPEP | "alanyl aminopeptidase, membrane [Source:HGNC Symbol;Acc:HGNC:500]" | 1887 | -6.541 | -0.0402 | Yes |
| 20 | NRCAM | neuronal cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:7994] | 1948 | -7.990 | 0.0103 | Yes |
