CTD

Having a list of genes for the potentially damaging SNPs, we can now look for relationships between these genes. There are several tools useful for this, including CTD, g:Profiler, and DAVID. For this example we will use the CTD tool to extract pathway information from the Comparative Toxicogenomics Database. Select the join results from the previous step, and column 27 which has the gene symbols (blue box). The identifier type we are using is NCBI gene symbols (which are the same as HUGO), and for the output we want the pathways. Then click Execute.

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