Laboratory of Ross Hardison

Current Directory Entry

Pictured are (L to R) April Cockburn, Cheryl Keller, Alexander Wixom (now a postdoctoral fellow at the Mayo Clinic), Ross, Belinda Giardine, Guanjue Xiang (now a postdoctoral researcher at the Dana Farber Cancer Research Center). Not pictured: Camden Jansen, postdoctoral researcher. Photo from September 2019.

Photos of lab folks in earlier years

Ross Hardison is the T. Ming Chu Professor in the Department of Biochemistry and Molecular Biology of The Pennsylvania State University. Ross and his co-workers measure transcriptome profiles and use epigenetic marks (such as transcription factor occupancy and histone modifications) and comparative genomics to predict gene regulatory modules. We test these predictions for function in the laboratory, and work to pull all this together into a more thorough understanding of global regulation during hematopoiesis. The techniques developed and utilized in this research should be applicable to a wide variety of regulated systems and organismal groups.

Research

• Description of research
• The VISION project: ValIdated Systematic InterpretatiON of epigenomic data in hematopoiesis. This is the portal for extensive epigenomic datasets, integrative modeling, candidate regulatory elements with predictions of epigenetic regulatory potential and 3D-interaction frequencies in human and mouse blood cells, along with visualization tools.
• Publications
  • Publications and citations compiled in Google Scholar.
  • Description, projects, publications, citations compiled in Penn State PURE
  • For publications listed in PubMed, click here.
  • A list of all published articles and books, along with links to full text for most articles since 1996

Research centers and connections

• Center for Eukaryotic Gene Regulation
• Center for Computational Biology and Bioinformatics (CCBB)
• The Huck Institutes of the Life Sciences
• Galaxy empowering transparent and sophisticated informatics and analyses for the broad community of life sciences. Use it and love it!
• The Encyclopedia of DNA Elements, or ENCODE, data portal. The Hardison lab contributed 134 datasets to this consortium effort to find functional elements in the human and mouse genomes.
• Globin Gene Server
• Much work was done in a long-standing collaboration with Dr. Webb Miller.

Teaching

• Textbook and course material, Working with Molecular Genetics, in four forms:
  • It initiated the Genetics section of the BioWiki Dynamic Textbook Project at the University of California at Davis (directed by Dr. Delmar Larsen)
  • Online textbook html and pdfs
  • Textbook Microsoft Word documents with figures embedded
  • Course material, comprised of lecture presentations (ppt), for a molecular genetics course based on Working with Molecular Genetics, 2002.
• Course on Functional Genomics: Illuminating the dark matter of the genome
• Lecture presentations used in my online course in Genomics, BMMB 551.

Hardison family material

• Stories and photos of the Hardison and related families are here.

  Page created: Wednesday, 12-Jan-2005, last modified 04-Feb-2021